The Latin America region sustains around one-tenth of global population; while average GDP per capita is medium-high, the region exhibits great socio-economic contrasts. Formally, the registered generated waste of electrical and electronic equipment (WEEE) is lower than the world average but there is a substantial informal recycling and reuse system. In this chapter, we determine the impact of public policy instruments through systems dynamics modeling of the physical, economic, and information flow of household TV, fridges, computers, mobile phones, and light bulbs life cycle. We estimate country performance based on data drawn from major cities. Three countries are modeled, each with different WEEE management characteristics. Using sensitivity scenarios, we determine the policies with stronger effect in reuse, collection, dismantling, recycling, and material recovery. The outcome variables evaluated are hazardous, valuable, and landfill materials, as well as energy consumption; informal recoverers are intrinsically included in the models as well as the reduction of environmental and health impacts, under the umbrella of an integral management model.