Abstract The constant changes in the business environment force managers to propose strategies aimed at continuous improvement, strengthening the objectives of the organization and its alignment with new technologies; It is here that the relationship between the performance of the information technology government and the organizational culture arises; Generating the intention of this theoretical approach that is framed in analyzing and interpreting the influence of organizational culture in the application of information technology government in the “Universidad Francisco de Paula Santander, Seccional Ocaña”. The information technology government represents a wide area of corporate governance, being necessary to ensure the alignment of the strategies and objectives of the organization as described by the information technology governance Institute; It should be noted that the first principle of COBIT 5 implies the satisfaction of the interested parties, which include the human talent of the organization, therefore there is a close link between the human factor and the performance of the information technology government, finally it is sought to unveil how the organizational culture affects the performance information technology governance within the institution of the “Universidad Francisco de Paula Santander, Seccional Ocaña”.