<b>Background:</b><i>Streptococcus pneumoniae</i> is the most common bacterial cause of community-acquired pneumonia (CAP). About 20% hospitalized CAP patients develop cardiovascular events (CVEs). We hypothesized that pneumococcal bacteremia (PB) is needed to cause CVEs as observed in preclinical models. <b>Aim:</b> To assess whether PB is associated with CVEs in hospitalized adults with pneumococcal CAP. <b>Methods:</b> We conducted a secondary analysis of a database from international, multicenter, observational cohort studies involving 18 hospitals in 7 countries. Primary outcome was a composite of CVEs, defined as at least one of the following: new or worsening arrhythmia, new or worsening heart failure (HF), or myocardial infarction (MI). New CVEs referred to patients without prior CV conditions. PB was defined as at least one positive blood culture for pneumococcus. Patients with positive respiratory sample and/or urinary antigen were defined as non-PB (NPB). <b>Results:</b> We included 2088 patients, 921 (44%) PB vs 1167 (55.9%) NPB. CVEs occurred in 275 (13%) patients, with a higher rate for PB (15%) vs NPB (12%), respectively (p = 0.02). There were 316 CVEs in total: 25 (7.9%) MIs, 150 (47.5%) new and 51 (16.1%) worsening arrhythmias, 51 (16.1%) new and 39 (12.4%) worsening HF. The rate of specific CVEs in PB vs NPB patients were 16 (1.7%) vs 9 (0.8%) MIs (p = 0.07), 86 (9.3%) vs 64 (5.5%) new arrhythmias (p = 0.01), 19 (2.1%) vs 32 (2.7%) worsening arrhythmias (p = 0.39), 18 (2.0%) vs 33 (2.8%) new HF (p = 0.25), and 23 (2.5%) vs 16 (1.4%) worsening HF (p = 0.07), respectively. <b>Conclusions:</b> PB CAP is associated with a higher rate of CVEs, primarily driven by higher incidence of new new-onset cardiac arrhythmias.