The ballistic performance of multilayered armor system (MAS) with front ceramic tile, followed by a laminate of up to 50 vol.% of fique fabric-reinforced epoxy matrix and back by a 5062H34 aluminum alloy was evaluated. The backface signature (BFS) caused by the bullet in a block of clay witness behind the target was used to evaluate the MAS ballistic performance according to international standards. The results using high-velocity 7.62 mm ammunition show a BFS similar to a MAS second layers of Kevlar™ laminate with the same thickness. The Weibull analysis statistically provides the reliability of BFS test results. Fracture examinations by scanning electron microscopy (SEM) revealed that the epoxy-fique fabric composite has different types of energy dissipation mechanisms. These are the same capture of ceramic fragments by a mechanic of incrustation presented in Kevlar™ laminate. Among the tested materials, the 40 vol.% fabric composite was found to be a better alternative to replace Kevlar™. The lower cost of the epoxy-fique fabric composite is an additional advantage that favors its substitution for the aramid fabric.