Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia with a specific histological pattern involving varying degrees of alveolar wall inflammation or fibrosis, and with a temporal uniformity of lesions.The organized component can be found at different degrees, and the presence of a histologically organized component does not exclude a diagnosis of NSIP.Acute respiratory failure is rare in NSIP.A female patient who presented to our clinic with radiological findings of widespread consolidation and acute respiratory failure was diagnosed with NSIP with organized pneumonia through a surgical lung biopsy.The patient responded rapidly to steroid therapy, and the clinical findings improved dramatically.We present our case in order to emphasize the importance of treatment in the event of respiratory failure in idiopathic NSIP with organized pneumonia, and recommend rapid diagnosis and treatment.