The anesthetic technique for tumors resection that affect extensive motor areas with an awakened patient, poses a challenge for surgical teams.The advancement in neuroimaging and the incursion of neuronavigation as a surgical tool, allow to reduce motor sequelae and extend the safety margins in the resection of these types of tumors.The case report of a 25-year-old patient with a 6 glioma, 5 cm, successfully resected under anesthesia with awake patient and neuronavigation techniques is presented.The Global Deterioration Scale (GDS-FAST) after three years of the procedure indicates a very mild cognitive deficit.The use of neuronavigation under anesthesia with fully awake patient becomes the best therapeutic alternative in the approach of tumors that compromise the eloquent areas allowing to establish safe margins for tumor resection and significantly reducing subsequent neurological sequelae.