Solubility data of bioactive compound such as ethylparaben (EtP) are important for the scientific and community. Therefore, in present study, solubility, solution thermodynamics and solute-solvent interactions (at molecular level) of EtP in nine cosolvent mixtures (1-propanol {n-PrOH) (1) + methanol (MeOH) (2)} including pure solvent (methanol and 1-propanol) at three different temperatures, i.e. (T =283.2 K, 298.2 K, and 313.2 K) and constant pressure (p = 0.1 MPa) were studied. Experimental solubility of EtP (expressed in mole fraction) was observed highest in n-PrOH at 313.2 K, so, mole fraction solubility of EtP (x3) increases when temperature arises and increases with n-PrOH proportion increasing. Ideal solubilities of EtP were estimated using their thermal parameters at three different temperatures. Ideal solubilities of EtP were observed similar to experimental solubilities of EtP at each temperature. With the help of ideal solubilities of EtP, activity coefficients were estimated. Based on estimated values of activity coefficients, highest interactions at molecular level were observed in rich-MeOH mixtures. Apparent thermodynamic analysis data showed endothermic and enthalpy-driven dissolution of EtP in each solvent and mixture studied. Solubility behavior was adequately correlated by means of the van’t Hoff and Yalkowsky-Roseman models combined.