Background: Hookworms, cosmopolitan geohelmintiasis by Ancylostoma duodenale, and Necator americanus infect more than 1 billion people.Objective: The aim of this study was to present a clinical case of severe iron anemia and literature review report.Materials and methods: This was a descriptive study with a review of the clinical history and literature.Results: A 19-year-old patient, who was referred to the Hospital Militar Central, presented with paraclinical signs showing severe anemia; abdominal pain for 3 weeks, with emesis and fetid liquid stools, with mucus, without blood, asthenia, adynamia, and feeling light-headed; generalized asymptomatic physical examination with pallor, tachycardia, and with the presence of low intensity systolic murmur in the aortic focus.He was diagnosed with severe microcytic hypochromic heterogeneous anemia with a probable ferropenic origin.He got a transfusion of red blood cells and was managed with o-meprazole, ferrous sulfate, and albendazole.Conclusion: In Colombia, the prevalence of hookworms is 13%, iron deficiency, 4.9%, and iron deficiency anemia in school children, 0.6%.