The leather industry produces a high yield of solid hazardous wastes that generate a major impact on the environment. At the same time, the use of dyes by different manufacturing industries, including the footwear industry, creates large amounts of colored wastewater that is hard to treat. In this paper, potential adsorbents based on the functionalization of solid waste from leather in the removal of anionic dye Congo Red were studied. Twelve different functionalized adsorbents were analyzed in terms of dye removal. From those, the best adsorbents were characterized and tested to determine their life cycle, pH dependency and the resulting phytotoxicity of the treated dye baths. Different kinetic models were evaluated to describe this adsorption process. It was found that functionalized leather adsorbents presented multi-linearity behavior when removing Congo Red. Life cycle analysis showed that the adsorbents presented a high yield of absorption until the third cycle of operation, while phytotoxicity tested showed reductions up to 50% in the toxicity of the treated dye baths.