Purpose: Colorectal cancer is a leading cause of mortality. Few reports investigating the surgical therapy of colorectal cancer in Colombia do exist. Therefore, we performed a retrospective analysis of patients undergoing surgery for colorectal cancer at our institution within a 10-year period. Methods: 244 patients were operated for colorectal cancer at our institution between 1994 and 2004. All patient data was retrospectively obtained through chart review. Short- and long-term morbidity and mortality were investigated with major objective on recidive-free survival and overall survival. Results: A total of 244 operations were performed, 205 (84.4%) of those were elective surgeries. ASA II classification had 93 of 142 colon cancer patients and 67 of 100 rectal cancer patients. Abdominoperineal resection was the most common procedure performed (24.2%). Operative mortality among all cases was 4.5% (11 of 244 patients), one death was possibly surgery-related. Overall survival in colon cancer patients was mean 4.77 years (±SD 0.95) for stage I, 4.66 years (±SD 0.58) for stage II, 2.94 years (±SD 1.08) for stage III, and 0.72 years (±SD 0.33) for stage IV. Overall survival in rectal cancer patients was mean 5.85 years (±SD 1.11) for the stage I, 3.30 years (±SD 1.13) for stage II, 3.02 years (±SD 0.60) for stage III, and 0.64 years (±SD 0.21) for stage IV. Overall survival among all colon and all rectal cancer patients was not significantly different at 10 years (Figure 1).Figure 1Conclusions: Surgery for colorectal cancer is performed with low perioperative mortality and morbidity at our institution. Long-term survival depends on cancer-stage at surgery, overall 10 year survival does not differ among all colon and all rectal cancer patients. [figure 1]