Introduction: Systemic sclerosis (SSc) is a chronic disease of the connective tissue that has manifestations in multiple organs, which commonly affects the gastrointestinal system, and the esophagus most of all. Because of the systemic implications, impacts not only on mortality, but also in morbidity and deterioration in the quality of life, we provide a description of a group of patients in whom high resolution esophageal manometry was performed and had symptoms suggestive of digestive envolvement by SSc. Methods: We conducted a retrospective analysis of a group of patients with a diagnosis of SSc that required high resolution esophageal manometry in Hospital Universitario San Ignacio physiology laboratory during January/2015 - March/2016 Results: Data were obtained from 23 patients of which 21 were women (91.3%), with an average age of 59,65 (10.63 ±) years, and an average time of disease of 7.83 years (± 6.57). The main indication was dysphagia for solids (69.9%). Our results shows aperistalsis in 87% of patients and only 3 studies were normal. Results were consistent with those described in world literature, that reports reflux or dysphagia as esophageal symptoms between 42% and 80% of the patients, and up to 50-90% have abnormalities in esophageal motility and lower esophageal sphincter. On the other hand, we reviewed endoscopic findings that showed the presence of hiatal hernia (43.5%) and signs of reflux (34.8%). Additionally is important to highlight that associated to the esophageal envolvement, Raynaud phenomenon was presented in 91.3% of the cases, pulmonary interstitial disease (17.4%) and cutaneous diffuse compromise (87%) which are being studied recently as predictors of early esophageal envolvement. Conclusion: The results of our study are comparable to those described in the literature in terms of digestive envolvement and manometric findings in SSc. Additionally, the role of high resolution esophageal manometry is the best tool for the evaluation of these disorders and it is suggested to do it in a early stage, not only when the symptoms are present, but is suggested too in the presence of extra- esophageal envolvement as Raynaud phenomenon, pulmonary and cutaneous disease, according to new physiopathological hypotheses.Table 1: Demographic characteristics on patients with SSc that went to high resolution esophageal manometry