The studies of mechanical resonators in the quantum regime not only provide insight into the fundamental nature of quantum mechanics of massive objects, but also introduce promising platforms for novel hybrid quantum technologies. Here we demonstrate a configurable interaction between a superconducting qubit and many acoustic modes in the quantum regime. Specifically, we show how consecutive Landau-Zener-St\"uckelberg (LZS) tunneling type of transitions, which take place when a system is tuned through an avoided crossing of the coupled energy levels, interfere in a multimode system. The work progresses experimental LZS interference to cover a new class of systems where the coupled levels are those of a quantum two-level system interacting with a multitude of mechanical oscillators. The work opens up applications in controlling multiple acoustic modes via parametric modulation.