Productivity and quality are parameters of constant research and development in the machining industry. However, the concern for the environment and sustainability have forced a decrease in the limit of the use of cutting fluids. Given this, it is important to take into account solutions focused on satisfying these requirements. In this work, using MQL spray lubrication with the inclusion of TIO2 titanium nanoparticles in the turning process of AISI 304 steel, it has been possible to show improvements in the surface quality and decrease in the wear of the cutting tools. It was determined that the inclusion of 0.5% TiO2 in vegetable oil achieved an improvement in the surface roughness of 50%. In addition, under the conditions of the tests, the flank wear of the cutting tools was reduced by 25%.