Septic thrombosis of the lateral sinus is a rare complication of otitis media; currently, it hasn't been found a case report of septic thrombosis of the lateral sinus in the medical literature of Colombia and, in addition to this, there is no consensus in the management of this pathology. Hence the importance of the present case, which is a 3-year-old male patient, who presented a clinical picture of 7 days of evolution characterized by right otalgia and fever, which after the administration of amoxicillin for 5 days got complicated and showed symptoms of severe headache, photophobia, nausea and vomiting.