The increase in global energy demand promotes the use of energy crops and agroindustrial residues for biogas or methane production.In agro-business, the coffee waste as mucilage is a major source of carbohydrates mainly galactose and glucose.The aim of this study is to optimize the anaerobic digestion process of coffee mucilage for methane production.An experimental design 2 3 full factorial with center points was set, generating 20 treatments, considering factors such as pH, temperature and initial sugar concentration.Optimal conditions for the methane production from coffee mucilage estimated by statistical software were pH 8.2, temperature 37ºC and sugar concentration 27 gL -1 .Through this research project, the experimental optimum conditions for the production of methane from coffee mucilage were used, which were pH 8.2, temperature 37 °C, sugar concentration 25.5 gL -1 and 313 mL methane (atmospheric pressure), the last exceeded the estimated optimal condition.