Based on a mixed-methodology research, this article shows that the socio-economic profile of the majority of women deprived of their liberty in Colombia is characterized by a multiple marginality situation, due to the connection between gender and low socio-economic status. Likewise, this text explores the specific needs and the experiences of these women in relation to work, by considering their profile and role as primary caregivers. The analysis is divided into three moments: before detention, in prison, and after returning to the community where it is evident that prison strengthens inequality linked to their gender and low socio economic status. These social-economic vulnerability conditions include precarious employment. It is fundamental to offer programs, interventions, and services that consider women’s profile and their situation, particularly, training in prison for a job that will be productive and useful when released. Additionally, it is important to rethink the scope of labor law in relation to prison work.