<h3>Background:</h3> Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized chronic joint inflammation. RA and ageing are associated with comorbidities such as cardiovascular disease, malignancies and osteoporosis, these conditions have an important effect on the management of RA. These comorbidities can be associated with higher mortality, poor life quality, and the increasing of costs for the health system. <h3>Objectives:</h3> To describe the prevalence of comorbidities and characteristics of a Colombian unicentric big cohort that assist to a RA specialized center. <h3>Methods:</h3> We performed a descriptive analysis; our main goal was to provide real-life data regarding characteristics of patients with RA. We collected sociodemographic information, DAS28, and prevalence of comorbidities regarding hypertension, cerebrovascular disease, diabetes mellitus, osteoporosis, renal chronic disease, or Sjogren's syndrome. We calculated means, and standard deviations for continuous variables and categorical variables were presented as rates. We estimated the prevalence of comorbidities and performed a bivariate analysis. <h3>Results:</h3> We reviewed the medical charts of 6541 patients, 82% were female and 18% male; median age was 60 years RIQ (50-67), regarding disease activity, mean DAS28 was 3.34 ± 1.28. The prevalence of comorbidities was 36%, the most common disease was high blood pressure followed by osteoporosis, see table 1. When we compared DAS28 and comorbidities 11% of patients who were in moderate or severe disease activity had one or more comorbidities. The relationship between disease activity and comorbidities was not associated and it was not statistically significant (P>0.05) <h3>Conclusion:</h3> As other studies have shown high blood pressure is the most common disease among patients with RA followed by osteoporosis(1, 3). s. According to these results it is important to consider the patient's context, medical conditions, and the number of comorbidities in order to understand the complexity of the management of patient with RA. Additionally, it is important to explore barrier and health care services in order to plan a realistic plan where a patient is managed with all comorbidities. <h3> Disclosure of Interests:</h3> Anggie Aza: None declared, Michael Cabrera: None declared, Fernando Rodriguez: None declared, Pedro Santos-Moreno Grant/research support from: Dr Santos has received research grants from Janssen, Abbvie and UCB, Speakers bureau: Dr Santos has received speaker fees from Sanofi, Lilly, Bristol, Pfizer, Abbvie, Janssen and UCB
