Many rings and algebras arising in quantum mechanics can be interpreted as skew Poincaré–Birkhoff–Witt (PBW) extensions. Indeed, Weyl algebras, enveloping algebras of finite-dimensional Lie algebras (and its quantization), Artamonov quantum polynomials, diffusion algebras, Manin algebra of quantum matrices, among many others, are examples of skew PBW extensions. In this paper, we extend the classical Ore and Goldie theorems, known for skew polynomial rings, to this wide class of non-commutative rings. As application, we prove the quantum version of the Gelfand–Kirillov conjecture for the skew quantum polynomials.