Objective: to determine the association between occupational ionizing radiation exposure in the cardiovascular catheterization laboratories staff and development of lens changes.Methods: a cross-sectional study was made.Participants were recruited at the XIII Colombian Conference of Interventional Cardiology and SOLACI conferences in Bogotá -Colombia 2017.Informed consent was obtained from all study participants.Demographics and clinical data were collected.Associated lens changes were determined according to the ionizing radiation exposure status.Results: a total of 89 subjects (178 eyes) participated in the study.In general, the mean age was 40 years old, ranging from 19 to 78 years old.Distribution according gender was 55.3% male and 44.7% female.31 subjects (62 eyes) were deemed to have not occupational exposure to radiation and 58 subjects (116 eyes) with a history of occupational radiation exposure.Exposed eyes had twice risk for present subcapsular posterior lens opacity compared to non-exposed eyes.The subjects with older age and physician role were associated to the presence of lens opacity, with a p value 0.001 in both cases.Likewise, exposed subjects with any lens opacity had a high mean occupational lifetime, with a p 0.001.Conclusions: this study confirms a statistically significant increase in radiation-associated subcapsular lens changes in the eyes of interventional cardiology staff compared to unexposed controls.