We present two women who consulted the emergency department for acute abdominal pain, which began a few hours after their arrival in Bogotá DC, associated with anemic syndrome and paraclinical findings suggestive of sickle cell anemia, which was confirmed with protein electrophoresis in the outpatient clinic. Sickle cell disease, known as sickle cell anemia, is a structural hemoglobinopathy of genetic origin that causes vasocclusive symptoms with secondary tissue ischemia that generates pain crises, which is exacerbated, among other reasons, by changes in temperature and atmospheric oxygen pressure. It is an important cause of acute pain in black patients who attend the emergency room, often coming from warm places.