Hypertension is a major risk factor for cardiovascular disease.Its prevalence is increasing worldwide, and is more common in low and middle-income countries.The effectiveness of hypertension treatment is determined by health cost, awareness, and patients' compliance with the treatment.People worldwide with an adequate control of hypertension correspond to a very small percentage in low and medium income countries as the Latin America ones.Between the causes to explain these are the low availability, affordability and adherence to treatment with multiple pills.It has been proposed that fixed dose combination therapy could improve the availability, affordability, adherence and control of hypertension.This article aims to review the evidence, showing that fixed dose combination can improve adherence, decrease health cost and improve control of hypertension.Improvement in hypertension control with fixed dose combination could make an important contribution to efforts to fight against the global cardiovascular morbidity and mortality.