Evaluation of sowing density is an important factor for achieving maximum yields without affecting other agronomic traits. Field experiments were conducted during three consecutive years (2008, 2009 and 2010) to determinate the effect of four sowing density (62,500; 83,333; 100,000 and 142,857 pl ha−1) on yields and its components of two cotton varieties, ‘Delta Pine 16′ and ‘SN-290′ in Venezuela. The traits evaluated were lint yield, boll weight, number of seeds per boll, 100-seed weight, and fiber content. Highly significant differences (p ≤ 0.01) were observed among genotypes, sowing density and their interactions for all traits. Sowing density was not affected by year factor. High lint yield was found in ‘SN-290′ (4216.2 kg ha−1) at 100,000 pl ha−1; and in ‘Delta Pine 16′ (3917.3 kg ha−1) at 83,333 pl ha−1. The highest sowing density (142,857 pl ha−1), decrease lint yield and yield components in the genotypes. The highest boll weight was obtained by ‘SN-290′ with 6.4 g in average. All sowing densities evaluated resulted in lint percentages above 40%. Cotton lint yield was positively correlated with all yield components. Our results indicate that highest lint yields could be obtained with sowing densities between 83,333 and 100,000 pl ha−1 depending upon varieties used across savannahs of Venezuela.