We seek to determine if the diagnosis of chorioamnionitis in placental freeze biopsy is related to unfavorable outcome in the newborn. Materials and methods: Prospective cohort of pregnant women with high suspicion of chorioamnionitis who underwent cord and membrane freezing biopsy with usual histopathological study, and it was related to the morbidity and mortality of the newborn. Results: freezing and paraffin were studied in 23 placentas with suspicion of chorioamnionitis; four were positive in both and 19 negative. Five developed early sepsis, all with clinical diagnosis of chorioamnionitis in their mothers, of which three were positive in both microscopic studies. Conclusions: early sepsis and mortality in children of mothers with chorioamnionitis diagnosed by freeze and paraffin biopsies were evaluated, showing an adequate relationship. The diagnosis by freezing was precise and early, positioning itself as a possible diagnostic tool that allows an early approach to both maternal and neonate with potential infection, in order to reduce adverse outcomes with impact on neonatal morbidity and mortality. Abbreviations: RN, newborn (s).