Abstract magnified image Novel 11‐amino‐6‐aryl‐6,7‐dihydroindeno[1,2‐ e ] pyrimido[4,5‐ b ][1,4]diazepin‐5(5a H )‐ones 4a‐f were prepared regioselectively by the tricomponent reaction of 4,5,6‐triaminopyrimidine 1, 1,3‐indandione 2 and aromatic aldehydes 3a‐f. The bicomponent approach, using 2,4,5,6‐tetraaminopyrimidine 5 and 2‐aryl‐ideneindandiones 6a‐f as reagents, afforded 9,11‐diamino‐6‐aryl‐6,7‐dihydroindeno[1,2‐ e ]pyrimido[4,5‐ b ]‐[1,4]diazepin‐5(5a H )‐ones 7a‐f in good yields and the regioisomeric 8,10‐diamino derivatives 8a‐c in lower yields. Both, bi‐ and tricomponent approaches were performed by microwave irradiation and all products were fully characterized by detailed NMR measurements.