The application of mineralogy in archeology has been growing in interest in particular in relation to establishing the origin of the clays used in the elaboration of ancient ceramic artifacts.The mineralogy did not show a clear relationship with the colors expressed by the pottery system defined by the archaeologists; that is, independent of the color of the slip, each group has the same mineralogical components.Fourteen Pre-Hispanic pottery sherds from the Mesa de Los Santos region (Colombia) were selected for mineralogical characterization by X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy.The objective of the work was to contribute to the knowledge of the production technology and elucidate a possible regional origin of these ceramics.The observed mineralogical phases were plagiocalse, quartz, potassium fledspar, clay minerals, micas, carbonate minerals, and iron oxides.Firing temperatures are in the ranges 600-800°C for almost all the analyzed samples.