Objective: To analyze the vulnerabilities of women cared for in a Reference Center to Women in Situation of Violence. Method: Qualitative study, from semi-structured interviews with 15 women, in 2017 and 2018. Data analysis occurred through thematic content analysis. Results: The category “vulnerability of women in situation of violence” covered social isolation, fear, or shame in denouncing, financial dependence, loss of freedom, fragile self-esteem, lack of formal support, decision to denounce and seeking help, interpersonal bond, protective measure, and difficulty of access to information. Conclusions: Vulnerability was apprehended in its individual and programmatic dimensions, inter-related with the social dimension. These vulnerabilities must be considered in the formulation of policies for care of women in situation of violence, given that it is the first step for gender equality and eliminate violence against women