The linear and quadratic perturbations for a scalar-tensor model with non-minimal coupling to curvature, coupling to the Gauss-Bonnet invariant and non-minimal kinetic coupling to the Einstein tensor are developed. The quadratic action for the scalar and tensor perturbations is constructed and the power spectra for the primordial scalar and tensor fluctuations are given. A consistency relation that is useful to discriminate the model from the standard inflation with canonical scalar field was found. For some power-law potentials it is shown that the Introduction of additional interactions, given by non-minimal, kinetic and Gauss-Bonnet couplings, can lower the tensor-to-scalar ratio to values that are consistent with latest observational constraints, and the problem of large fields in chaotic inflation can be avoided.