Anticoagulation requires continuous monitoring because of the high risk of thrombotic and hemorrhagic complications. Success depends to a large extent on the education of the patient for adequate therapeutic adherence. Objective: to evaluate this adherence in the anticoagulation clinic of the hematology service of the San José Hospital of Bogotá DC (Colombia) during a period of three months. Methodology: descriptive cross-sectional study in which the ARMS scale was applied. The total score ranged from 12 to 48, with 12 being the perfect level and 48 the worst. Results: the questionnaire was applied to 106 patients. In the overall evaluation, the score was between 12 and 26 (average: 13.72, SD: 2.19), on the subscale on anticoagulant intake, between 8 and 19 (average: 9.12, DS: 1.58) and on the subscale according to availability of the medicine between 4 and 8 (average: 4.60, DS: 1.00). The best adherence was identified in item 5 (average: 1.01, DS: 0.13) and the worst in item 1 (average: 1.39, DS: 0.56). 35% (n = 37) obtained a perfect adhesion. Conclusions: the overall therapeutic adherence is good, but barriers related to the patient and the anticoagulant supply were identified, which justify the strengthening of patient education and the development of strategies for the timely delivery of the medication.