Introduction: Venous thromboembolism ( VTE ) is a leading cause of morbidity and mortality in cancer; and its occurrence leads to an increased number of hospitalizations. Therefore, we aimed to determine the trends in the annual rate of cancer-associated thrombosis ( CAT ) hospitalizations and measure its impact in patients with highly thrombogenic tumor types, such as pancreas, stomach and lung. Methods: We queried the 2009-2014 Nationwide Inpatient Sample database to identify adults with gastric, pancreatic or lung cancer. Hospitalizations in which VTE was among the top-three discharge diagnoses, were considered as CAT admissions. In-hospital outcomes of patients with VTE were compared to those without VTE. Using SPSS, version 24, we conducted a linear regression analysis for trend and binary logistic regression analysis to obtain adjusted odds ratios ( OR ) Results: From 3 million admissions, 149.577 (4.9%) were related to VTE. The patients were mainly white (68.9%) men (53.2%) with a median age of 69 (IQR:17) years; and the predominant tumor type was lung cancer (73.4%). Although the rate of CAT admissions remained steady during the study period (2009: 5.0% vs 2014: 4.9%, p <0.01), the inpatient mortality was higher among patients admitted with CAT (10.2% vs 9.3%, OR:1.11, CI: 1.08 - 1.13, p < 0.01). The negative effect of VTE on inpatient mortality persisted after adjusting for tumor type, metastatic disease and demographics (OR:1.11, CI: 1.08 - 1.13, p < 0.01). The median length of stay was 5 days in both groups (p<0.01), but the cost was significantly higher among those admitted with CAT (USD33,468 vs USD30,452, p <0.01). Figure 1 summarizes demographics ( A ) and trends ( B ) Conclusion: CAT admissions in patients with stomach, pancreas and lung cancer are associated with a higher inpatient mortality and its management is costly. Conceivably, risk stratification based on early mortality may assist in therapy and resources selection to improve outcomes and cost allocation.