The aim of this study is to evaluate and compare the response of the anisotropic maxilla bone, in the peri-implant region, when osseointegrated implants are placed in different angles, based on the stress and strain distribution obtained by finite element analysis. Models were created to represent a portion of a maxilla bone (upper first molar region) with two types of implants which have different thread geometry (squared and V-shaped) and material (Ti-6AL-4V ELI and grade IV Titanium). Compressive axial load was applied to anisotropic models of the bone tissues, assuming complete osseointegration. Results show that the increase of the implant angle leads to a more critical state, especially for strain distribution which cannot exceed the limit of 4000 microstrain. Squared thread implants are a better option for osseointegrated dental implant treatments when inclined positions are required. More detailed models should be created to represent the use of bone allografts in a patient after bone resorption happened.