The reconstruction surgery of Anterior Cruciate Ligament (ACL), precise drilling of tunnels is required to pass the graft. A Computer-Assisted Orthopedic Surgery user interface with Augmented Reality was designed to assist the procedure. However, the surgeon's interaction has limitations: mainly because the controls located out of reach and there is inconvenience when using the hands given that the surgical environment must be kept sterile. Two kind of hand-gesture interaction were evaluated within this research to establish the most suitable device., hand-recognition used by META glasses and hand-gestures detected by EMG muscle sensors used by MYO arm-band, so as to establish the most appropriate one to manage a CAOS. Efficiency, efficacy and satisfaction were evaluated through two experiments. The results showed their relevance and usefulness within the surgical environment. It was established that the MYO arm-band was efficient and possibly more effective at performing the tasks and was perceived as further satisfactory compared to the META glasses.