Zika virus (ZIKV) is a new TORCHS virus with a recent outbreak in Latin America and south of the United States. The virus can be vertically‐transmitted, with many implications for the placenta and the fetuses. Even though there are multiple cases of malformations in babies born from mothers infected with ZIKV, there is little detail about the effect of the infection in the tissues during development. In this study, four fetuses of the second and third trimester and a newborn, who died within few weeks, from mothers diagnosed with ZIKV were collected from The Legal Medicine Institute of Bogota in Colombia. The cases were subjected to a complete autopsy and the necropsy results were analyzed. For histologic examination, series of micro‐sections were stained with H&E or processed for immunostaining. Macroscopic findings included compromise of the placenta characterized by opacity and thickness of membranes. The fetuses presented severe edema in extremities and pulmonary hypoplasia. In addition, one case showed Potter facies and low implantation of ear and nose. The newborn also presented petechiae on the thoracic region. Microscopic examination showed severe endothelial lesions in ovular membranes associated with inflammation and dystrophic calcifications of maternal and fetal sides of the placenta. Additionally, there were signs of severe funisitis in the umbilical cord, and congestion of the lungs and accumulation of plasmocytes in the fetuses. Preliminary results suggest an association between damage of the placental barrier and facilitation of fetal infection. Also, there is evidence of inflammation throughout the fetus' and newborn's tissues, in all cases. A through examination of all organs would give a better overview of the morphological changes caused by the viral infection, which could help understand the infection and give insights into the mechanisms of transmission, prevention and future treatment strategies. Support or Funding Information School of Medicine. Universidad de los Andes. Bogotá ‐ Colombia This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .