Prediction of flow and mixing of powders is a difficult challenge that has not been solved yet.Different numerical methods have been used to find the solution to the mathematical models proposed, but there are no experiments to compare and validate the results.The method with the best approximation is the discrete element method (DEM).However, this method requires a high computational power.In this article, it was made a comparison between the experimental results obtained when mixing two powders in an oscillatory low shear mixing device, and the 3D simulation of the same equipment using liquids with the help of a commercial software of computational fluids dynamics, CFD.Experiments at different wall velocities and wall displacements were run.Results reveal that the mixing in solids and liquids present lots of similarities when working at low velocity.This velocity lets solids to stay in frictional regime and liquids in the laminar regime.A zone of no mixing at the bottom of the mixing cavity is presented in liquids which is similar to the triangular pattern of no mixing found in solids.The height of the no mixing zone depends on the time of mixing, and the displacement and velocity of the walls.Under laminar regime conditions, the Navier Stokes equations can be applied to the powders because the velocity profiles obtained are similar.