Technological advances and novel applications in areas such as industrial robots (eventually personal robotics), artificial intelligence, big data, 3D printing, the internet of things, biotechnology, blockchain, and others have revived the debate on how the development and implementation of technological innovations may displace labor. These technologies are allowing the innovation of products, services, and business models at unprecedented speed, in the same way they are putting at risk both qualified and unqualified jobs and occupations. Most of the specialized literature dealing with the issue of technology and labor comes from the economics discipline, but it is pertinent to discuss how this translates into the managerial, organizational, and strategic principles framed for the fourth industrial revolution.