Post-infectious bronchiolitis obliterans (PIBO) is a rare respiratory condition in children that is responsible for small-airway obstruction. <b>Aim:</b> To characterize a group of pediatric patients diagnosed with post-infectious bronchiolitis obliterans (PIBO) at a university hospital in Bogotá, Colombia, located 2,600 meters above sea level. <b>Methods:</b> A total of 19 cases were retrieved and used to develop an observational, descriptive, and retrospective study. <b>Results:</b> Most of the studied patients were female (63.1%), and (57.8%) involved a previous acute lower respiratory tract infections (ALTRI). The mean age for developing the episode was 18 months, the average hospitalization was 14.5 days. 21.5% of the patients required a pediatric intensive care unit (PICU), mechanical ventilation in 10% of those cases. Microbiological isolation was 30%, respiratory syncytial virus(VSR) 10.5% and 5% mixed infection (adenovirus and RSV). 31.7% home oxygen therapy. PIBO was diagnosed on average 40.3 months due recurrent wheezing, 31.5% of the cases had a previous diagnosis of asthma. Pulmonary function tests in 15.8%, and fixed obstruction was seen. All patients underwent high-resolution computed tomography (HRCT), with a mosaic pattern in 89.4% of the cases, followed by atelectasis (31.5%) and air entrapment (21%). Finally, the least-found disease was bronchiectasis, with 15.7%. <b>Conclusions:</b> Our studies associate PIBO with VSR and adenovirus coinfection. the diagnostic approach regarding PIBO requires a high level of suspicion based on a suggestive clinical history, and tomographic evidence of the characteristic changes in small-airway involvement.