Lymphedema can be described as swelling caused by impaired drainage as a consequence of lymphatic dysfunction. Surgical interventions and chemoradiotherapy applications in head and neck region malignancies cause damage to the lymphatic pathways leading to impaired lymphatic flow and secondary lymphedema. The current standard management for any type of lymphedema includes multi-layered short strech bandaging, manual lymphatic drainage (MLD), use of compression garment(s) and education, but there is no standard therapy protocol is available for head and neck lymphedema (HNL). We describe a patient with HNL in whom we used kinesio taping therapy combining with exercise and self-MLD in stead of multi-layered short strech bandaging and had an extremely good effect on lymphedema stage. Kinesio tape can be a very effective tool for home based or outpatient therapy programs with appropriate applications. Kinesio taping can not replace the short stretch bandaging but it can be another choice for suitable patients.