This review article presents different ways to synthesize polymer nanowires emphasizing the electrospinning technique, which is a simple, versatile, and suitable process for the production of unidimensional structures (1D), and the parameters that should be considered when using this method; besides, it accents the importance of processing parameters (voltage, distance, and flow), solution parameters (concentration, viscosity, and superficial tension), and environmental parameters (temperature and humidity). Finally, it shows the different applications of nanowires in fields such as energy, tissue engineering, environment, and food.