Introduction: Despite advances in treatment, opportunistic infections (OIs) are the major causes of morbidity and mortality among patients with human immunodeficiency virus (HIV). Objectives : To estimate the prevalence of OIs among insured HIV patients, and to establish its association with socio-demographic and clinical factors. Materials and methods: An observational with analytical perspective. We analysed 37325 records of insured people with HIV. A Bivariate analysis, using Chi-square and ANOVA, adjusted by Bonferroni and a multiple logistic regression for adult population were done to explore the association among any opportunistic infections, as response variable, and socio-demographic and clinical factors. Results: 18% experienced any opportunistic infection. The most frequent were tuberculosis and brain toxoplasmosis for adults, and pneumonias and diarrhoeas for under 13 years of age. The prevalence of any OIs was significantly higher in men (OR=1,5; CI 95% 1,4-1,6), >40 years of age (OR=1,6; CI 95% 1,3-2,0), forcibly displaced (OR=1,7; CI 95% 1,5-1,9), people belonging to Subsidized and Exception regimen (OR= 2,7; CI 95% 2,1-3,4). Regarding to Clinical Risk factor, OIs were statistically associated to time since diagnosis >10 years (OR= 1,6; CI 95% 1,5-1,7), people receiving TAR (OR= 4,4; CI 95% 3,9-5,1), and those with discontinuous treatment (OR= 1,7; CI 95% 1,6-1,8). The Multivariate analysis for adults in clinical stage A shown similar results. Conclusion: Despite the preventable of OIs, the prevalence is still high, and predominantly affects the disadvantaged people.