Solanum phureja is one of the most important crops for farmer economy in Colombia, and Phytophthora infestans is considered its main limiting disease. This pathogen is managed using chemical products, generating high production costs as well as environmental pollution. The use of resistant varieties is a strategy that is currently well positioned for the control of this disease, leaving the task of identifying superior parentals to plant breeders. Moreover, the analysis of general and specific combinatorial aptitudes of potential parental genotypes gains importance. The aim of this study was to establish the general and specific combinatorial aptitudes of five elite parental cultivars. For this, 979 clones were assessed. General combinatorial aptitude results show statistically significant differences for the Paola, Primavera and Ocarina parentals. On the other hand, the specific combinatorial analysis allowed concluding that the combinations Ocarina×Violeta and Primavera×Galeras contain non-additive effects involved in inheritance.