Objective: To establish the prevalence of class III malocclusion in patients between 5 and 21 years of age who attended a consultation in the Odontopediatrics and Orthodontics clinic of the School of Dentistry of the Universidad del Valle. Materials and methods: A cross-sectional retrospective descriptive study was conducted in 108 patients between 5 and 21 years of age, who attended dental practice in the Odontopediatrics and Orthodonticsspecialties of the School of Dentistry of the Universidad del Valle, during period 1 of January 2012 to December 31, 2016. The information was obtained from the Clinical Stories that were stored in theactive archive of clinical records of the Institution. descriptive statistics was used. The variables age, gender, presence of class III malocclusion, origin and socioeconomic stratum were categorized, and a univariateand bivariate analysis was carried out to determine the relationship of the variables among themselves, and to typify the geographic location and socioeconomic stratum from which they came. mostly thepatients treated in these specialties. Results: A class III prevalence of 26% was found, showing no difference between men and women. Conclusions: The study revealed a high percentage of presence of class III malocclusion in the population of 5 to 21 years old that attended to the specialties of Pediatric Dentistry and Orthodontics of the School of Dentistry of the Universidad del Valle. The high prevalence of class III malocclusion allows an approach to the management of this disorder by residents.