This paper presents an integrated ANP and DEMATEL technique applied to identify and prioritize Six Sigma projects for healthcare companies.identify the most representative Six Sigma projects and their priority.First, the Six Sigma evaluation structure is determined; then DEMATEL (Decision Making Trial and Evaluation Laboratory) is applied to calculate interrelations among healthcare criteria.Finally, the criteria weights are established by ANP (Analytic Network Process).An empirical case for a public hospital is presented, showing the effectiveness of the proposed technique.