The Antioquia batholith represents the magmatic record of the interaction between the Farallón and Caribbean plates with the NW part of the South American Plate during the Meso-Cenozoic. Several authors have reported zircon U-Pb ages and whole rock geochemistry in order to constrain the crystallization history of this batholith and its formation conditions. The present work aims to gather the existing data with new data obtained from the Ovejas batholith and La Unión stock, both genetically related to the main intrusion. Gathering our new data with information obtained in previous works, we conclude that the Antioquia batholith was constructed by successive pulses from ca. 97 to 58 Ma in an arc-related setting. The initial pulses are related to syn-collisional tectonics, during the early interaction between the Farallón plate and NW South America. The final pulses, that record Eocene ages, are related to a post-collisional setting, similar to that recorded in other plutons of the Paleogene magmatic arc of the Central Cordillera.