Malaria is a parasite disease with negative impact for the worldwide human health.This motivates research in new anti-malaric natural medicine, which have proved high potential in in vitro and in vivo experiments . The objective of this research in the in vitro evaluation is: taking into account the antimalaric activity, its cytotoxicity with 9 raw extracts are prepared after some of this plant leaves : Piper tricuspe, Plantago major, Solanum nudum , Gliricidia sepium found in the Colombian south Pacific in Tumaco, Narino. The antiplasmodic activity was evaluated for the 3D7 Y FCR3 strains prepared with P. tricuspe y S. nudum. Ethanol had a CI 50 24,41 y 16,59mg/mL for the strain FCR3 and 27,1 y 23,26 mg/mL for the strain 3D7, this, The cytotoxic activity valued in the cell line HepG2, bot extracts being low toxic. It should be noted also, the importance in the intention to find new antimalaric from the plants found in the communities in south Colombia.