The Nevado del Huila Volcano Complex is made of rocks that have intermediate to acid composition, calc-alkaline affinity and middle content in K2O. According to SiO2 content, there are three geochemical types: andesites ss, dacitic andesites and dacites. Adakitic tendence in more recent lavas and more dacitic composition. Behaviors of mayor elements, REE, LFSE and HFSE are typical of orogenic andesites of active continental margin. Isotopic composition Sr-Nd resemble to volcanoes of ZVN Andes (Ecuador’s volcanoes, Galeras and Nevado del Ruiz volcanoes from Colombia). Homogeneous isotopic rate Sr-Nd (87Sr/86Sr = 0,7041-0,7042 and 143Nd/144Nd = 0,51279-0,51283) are typical of mantle melts, with limited taking part of derived components of subduced slab or continental crust. Compatible and incompatible trace elements indicate that fractional crystallization is petrogenetic process that has controlled magmatic evolution. Besides to reject others mechanisms: crustal contamination and magmas mixing. These rocks have probably been generated from partial melting of enriched mantle wedge by components of subduced slab. Later fractional crystallization drove magmatic differentiation of this volcano complex.