The solubility of minoxidil in the aqueous binary mixtures of ethanol at different temperature are investigated and the obtained solubility data are fitted by using some cosolvency models including van't Hoff equation, Yalkowsky model, Jouyban–Acree model and Jouyban–Acree–van't Hoff model. The mean relative deviations (MRD%) are used to illustrate the models performance. Moreover, the apparent entropy, enthalpy, and Gibbs free energy of minoxidil dissolution process in the investigated solvent mixtures are computed using van't Hoff and Gibbs equations. Finally, by means of the inverse Kirkwood–Buff integrals preferential solvation of minoxidil by water is observed in water-rich and ethanol-rich mixtures.