Objectives: The main objectives of this study were to compare the risk of suicide, sociodemographic and clinical characteristics in 3 designated groups: dual diagnosis (DD), substance-related disorder without other comorbid mental disorder, and any mental disorder without the presence of co-occurring substance-related disorders. Materials and Methods: This was a cross-sectional study with secondary information source from a population study. Adults of both sexes between 19 and 65 years of age were included and were screened for 23 mental disorders, the data collection tool used was the Compositum International Diagnosis Interview (CIDI 3.0), which uses DSM IV diagnostic criteria. Suicide risk in individuals with DD and other mental disorders was compared. Results: In total, 303 adults between 19 and 65 years of age were included. In all, 63% were women. The median age was 41 and the interquartile range 21. The prevalence of DD was 2.0% in the last 12 months and the prevalence of suicidal behavior was 7.6%, any substance abuse disorder 4.8%, any mental disorder without substance abuse 17.4%. An association of suicidal behavior with DD was found [odds ratio (OR), 13.85; 95% confidence interval (CI), 2.62-73.09) with grouped substance-related disorder (OR, 9.61; 95% CI, 2.49-37.00) and grouped mental disorders (OR, 4.97; 95% CI, 2.07-11.92). Conclusions: A higher risk of suicide was found in DD compared with noncomorbid mental disorders or substance-related disorder.