Key Teaching Points•Percutaneous transhepatic access is a safe and feasible method for atrial tachyarrhythmia ablation in patients with complex congenital heart disease and interrupted inferior vena cava.•The use of long steerable sheaths via percutaneous transhepatic venous access greatly improves catheter stability and manipulation during mapping and ablation of atrial tachyarrhythmias.•Closure of the hepatic parenchyma with vascular coils is a safe option to prevent hemorrhagic complications in patients undergoing percutaneous transhepatic access using large-caliber sheaths. •Percutaneous transhepatic access is a safe and feasible method for atrial tachyarrhythmia ablation in patients with complex congenital heart disease and interrupted inferior vena cava.•The use of long steerable sheaths via percutaneous transhepatic venous access greatly improves catheter stability and manipulation during mapping and ablation of atrial tachyarrhythmias.•Closure of the hepatic parenchyma with vascular coils is a safe option to prevent hemorrhagic complications in patients undergoing percutaneous transhepatic access using large-caliber sheaths.