Introduction: Nodular lesions and painful, symmetrical, erythematous plaques located predominantly on the extensor surfaces of the lower limbs, meaning that an appropriate clinical analysis should be performed, since it involves a wide range of causes.Case Report: We present a case report of a 25-year-old male patient diagnosed with sarcoidosis.His first clinical manifestation was the appearance of lesions compatible with erythema nodosum, accompanied by polyarthralgias of inflammatory characteristics predominantly in the lower limbs.The presence of noncaseating granulomas is demonstrated in taken biopsies.Erythema nodosum is an acute septal panniculitis of subcutaneous fat without signs of true vasculitis, and is the most common clinical-pathological variety of panniculitis.Being a reactive cutaneous process, it can be triggered by a long list of infectious, inflammatory disorders, malignant neoplasms and medications.Conclusion: Erythema nodosum is usually benign, its approach requires a practice that focuses on the determination of concomitant pathologies.