This article offers a panorama of symbolic relations present in the artifacts of the Neogranadine viceregal silver-smithing, constructed from the research of 106 objects and 48 archive documents. From the vision proposed by John Law and Bruno Latour, the article studies artifacts as “actants,” whose function, form, and materiality constitute semes, identified through iconological and technological footprint analysis. From there, it is possible to unveil the network of connotations that sustained the trade of silver-smithing in the Neogranadine context of the 18th century, that evidences the central role of the Catholic, Baroque, and Counter-Reformation mentality. It also unveils the composition of its imagery in the practices of the silversmiths guild and their clients, which were a reflection of colonial society, where honor derived from devotion was placed before the normative corpus of the Spanish Empire.