This article discusses the results of a pilot research strategy for monitoring environmental hazards derived from the use of mercury in artisanal gold mining in the Alto Cauca region, Colombia. During 2016 and 2017, a transdisciplinary approach was established to inquire on the health, environment, and territorial problems originated from artisanal mining. In this article, we specifically focus on how this particular issue affects women in the area. We establish a closed-loop approach for integrating social action research with analytical sciences/engineering to understand risks associated with Hg 2+ levels in artisanal and small-scale gold mining in the Cauca department. We develop a platform known as closed-loop integration of social action and analytical chemistry research.